Abstract: A novel rutin (RT) electrochemical sensor was fabricated by using reduced graphene oxide (rGO)/magnetite (Fe3O4)/silver nanoparticle (Ag)-molecularly imprinted polymer (MIP) composite to modify screen-printed electrode (SPE). The ternary composite of rGO/Fe3O4/Ag was prepared by the one-step solvothermal method. Subsequently, RT molecules were absorbed on the surface of rGO/ Fe3O4/Ag due to the electrostatic force. Finally, the MIP was achieved by a polymerization reaction. The prepared composite was investigated by FTIR, XRD and VSM. The morphologies and electrochemical properties of different electrodes were characterized with FE-SEM, EIS, CV and DPV. Under the optimal conditions, the SPEŚrGO/Fe3O4/Ag-MIP electrode exhibited highly sensitive and selective in determining of RT. The linear detection ranges (LDRs) were 1.0 x 10-2 to 10.0 μM (R=0.9978) and 10.0 to 3.0 x 103 μM (R=0.9965). The limit of detection (LOD) was as low as 4.2 x 10-3 μM (S/N=3). The proposed electrode was renewable, stable and reliable. It was used for determining RT in pharmaceutical samples with satisfactory results, confirming its promising application in routine RT analysis.
Template and target information: rutin, RT
Author keywords: Rutin, Reduced graphene oxide, Magnetite, Silver nanoparticles, molecular imprinted polymer, Screen-printed electrode