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Reference type: Journal
Authors: Iskierko Z, Noworyta K, Sharma PS
Article Title: Molecular recognition by synthetic receptors: Application in field-effect transistor based chemosensing.
Publication date: 2018
Journal: Biosensors and Bioelectronics
Volume: 109
Page numbers: 50-62.
DOI: 10.1016/j.bios.2018.02.058
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0956566318301593

Abstract: Molecular recognition, i.e., ability of one molecule to recognize another through weak bonding interactions, is one of the bases of life. It is often implemented to sensing systems of high merits. Preferential recognition of the analyte (guest) by the receptor (host) induces changes in physicochemical properties of the sensing system. These changes are measured by using suitable signal transducers. Because of possibility of miniaturization, fast response, and high sensitivity, field-effect transistors (FETs) are more frequently being used for that purpose. A FET combined with a biological material offers the potential to overcome many challenges approached in sensing. However, low stability of biological materials under measurement conditions is a serious problem. To circumvent this problem, synthetic receptors were integrated with the gate surface of FETs to provide robust performance. In the present critical review, the approach utilized to devise chemosensors integrating synthetic receptors and FET transduction is discussed in detail. The progress in this field was summarized and important outcome was provided
Template and target information: Review - FET-based sensors with synthetic receptors
Author keywords: synthetic receptor, molecularly imprinted polymer, Electrical transduction, field-effect transistor, Extended-gate field-effect transistor

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