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Reference type: Journal
Authors: Wan YC, Liu YJ, Liu C, Ma HT, Yu HF, Kang JW, Gao CL, Wu ZG, Zheng D, Lu B
Article Title: Rapid determination of neomycin in biological samples using fluorescent sensor based on quantum dots with doubly selective binding sites.
Publication date: 2018
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 154
Page numbers: 75-84.
DOI: 10.1016/j.jpba.2018.02.028
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0731708517328959

Abstract: A new analytical method was developed to detect neomycin in complex biological samples using molecularly imprinted polymer to construct an optical sensor. Fluorescent neomycin-imprinted polymers (fMIPs) containing both imprinted cavity and boronate affinity site were synthesized on the surface of silica-modified quantum dots. The fMIPs exhibited high selectivity to neomycin by having two binding sites for the target analyte. Neomycin analogues (competing for imprinted cavity) and D-glucose (competing for the boronate affinity site) did not affect the selectivity of the fMIPs. When combined with a fluorescent microplate reader, the obtained fMIP sensor displayed a linear concentration-dependent fluorescence quenching in response to neomycin in the range of 2-1000 μg/L, with a limit of detection as 0.16 μg/L. The fMIP sensor was able to detect trace neomycin in biological samples accurately after simple sample pre-treatment. The sensitivity of the fMIP sensor was higher than HPLC equipped with a fluorescence detector. The fMIP sensor containing the doubly selective binding sites provides a selective, sensitive, accurate, and high through-put approach for neomycin monitoring
Template and target information: neomycin
Author keywords: fluorescent sensor, Neomycin, Molecularly imprinted polymers, boronate affinity, Quantum dots, biological samples

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