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Reference type: Journal
Authors: Zhou J, He XW, Guo HS
Article Title: A molecularly imprinted polymer receptor for the enantiomeric recognition of amino acid hydantoins mimicking cooperative hydrogen bonds between nucleotide bases.
Publication date: 2000
Journal: Chinese Journal of Chemistry
Volume: 18
Issue: (4)
Page numbers: 482-488.
DOI: 10.1002/cjoc.20000180405
Alternative URL: http://sioc-journal.cn/chub/18040482.pdf

Abstract: Using acrylamide as hydrogen bonding functional monomer and (5R)-5-benzylhydantoin as template, a molecularly imprinted polymer was prepared in a polar solvent, which exhibited good enantiomeric recognition properties. The binding characteristics and selectivity of the polymer were evaluated by batch methods. Scatchard analysis showed that two classes of binding sites were produced in the polymer matrix and their dissociation constants were calculated to be 3.5 x 10(-5) mol/L and 4.3 x 10(-4) mol/L, respectively, by utilizing the model of multiple independent classes of binding sites. These results were more reasonable than those obtained by Scatchard analysis, which was in agreement with the prediction of the binding characteristics of the polymer by exploring the effect of acrylamide on UV spectra of (SR)-5-benzylhydantoin. The substrate- and enantio-selectivity of the polymer was investigated. Finally, the study of effect of water on the chiral separation factor of the polymer further proved that the hydrogen bonding interactions played an important role in the recognition of the acrylamide-based molecularly imprinted polymers
Template and target information: (5R)-5-benzylhydantoin


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