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Abstract: Objective: To establish a preparation method of molecularly imprinted mesoporous silica material for selective enrichment of fluoroquinolones drug residues in codfish. Methods: A new type of molecularly imprinted hybrid mesoporous silica material based on phenyl-and amino-siloxane was synthesized by the molecular imprinting technique and co-condensation method. Under the optimal condition, the ofloxacin, lomefloxacin and sarafloxacin residues in codfish were determined by solid-phase extraction coupled with high performance liquid chromatography. Results: An enrichment factor of 8.56 was obtained under optimum on-line solid phase extraction conditions. The recoveries of fluoroquinolones in fish samples at 0.05, 0.10 and 0.50 mg/kg were in the range of 79.2%-95.2% with the relative standard deviation (RSD) of 2.2%-4.9%. The limit of detection (S/N=3) and limit of quantitation (S/N=10) of the proposed method were 6.82-14.45 μg/kg and 22.73-48.45 μg/kg, respectively. Conclusion: The sample treatment method is selective, simple and rapid, which can be used for the separation and detection of fluoroquinolones in codfish samples.
Template and target information: fluoroquinolones, ofloxacin, lomefloxacin, sarafloxacin
Author keywords: molecularly imprinted mesoporous silica materials, Solid-phase extraction, codfish, fluoroquinolines