MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Sorribes-Soriano A, Esteve-Turrillas FA, Armenta S, Montoya A, Herrero-Martínez JM, de la Guardia M
Article Title: Magnetic molecularly imprinted polymers for the selective determination of cocaine by ion mobility spectrometry.
Publication date: 2018
Journal: Journal of Chromatography A
Volume: 1545
Page numbers: 22-31.
DOI: 10.1016/j.chroma.2018.02.055
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967318302395

Abstract: Magnetic molecularly imprinted polymers (MMIPs) were prepared for cocaine recognition by bulk polymerization in the presence of magnetic nanoparticles (MNPs). Two reagents (polyethylene glycol (PEG) and 3-(trimethoxysilyl)propyl methacrylate (V)) were used for MNPs modification. MMIPs were characterized and compared in terms of loading capacity, reusability, accuracy and precision for the extraction of cocaine from saliva samples. It was observed that V-MMIPs gave higher physical stability than PEG-MMIPs. Thus, V-MMIP were used for the analysis of cocaine users saliva. The developed procedure based on ion mobility spectrometry (IMS) provided limits of detection and quantification of 4 and 14 μg L-1, respectively, and recoveries in cocaine free saliva samples spiked at 80, 270 and 560 μg L-1 ranging from 80 to 99%. Results found by the proposed method were statistically comparable to those obtained by two reference procedures; a lateral flow immunoassay and an ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Therefore, MMIP-IMS can be considered as a fast, selective and sensitive alternative to reference methods with affordable cost avoiding the requirement of skilled operator
Template and target information: cocaine
Author keywords: Cocaine, ion mobility spectrometry, magnetic nanoparticles, Magnetic molecularly imprinted polymer, Saliva


  Krypton periodic table mug  Scientist peptide mug  I shop perodically customisable tote bag

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner