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Abstract: A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. The synthesis was conducted via a non-covalent imprinting methodology, using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties and elution (selectivity and reversibility) conditions were optimized. The selected molecular imprinted polymer had a molar ratio composition of 1:6:45 (template: functional monomer: cross-linker). The proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration and Youden calibration were carried out in order to evaluate constant and proportional errors due to the matrix. The developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays.
Template and target information: 2-amino-5-chlorobenzophenone, oxazepam