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Reference type: Journal
Authors: Pessagno F, Hasanah AN, Manesiotis P
Article Title: Molecularly imprinted 'traps' for sulfonylureas prepared using polymerisable ion pairs.
Publication date: 2018
Journal: RSC Advances
Volume: 8
Issue: (26)
Page numbers: 14212-14220.
DOI: 10.1039/C8RA01135D

Abstract: A novel approach towards recognition of sulfonylureas based on a polymerisable ion pair is presented. A solution association constant >10^5 M-1 between the model target glibenclamide and 4-vinylbenzyltrimethylammonium methacrylate is measured, and the formation of 1 : 1 complexes verified. Subsequently prepared stoichiometrically imprinted polymers exhibit exceptionally high affinity and binding capacity for glibenclamide, owing to synergistic binding of both the neutral and deprotonated form of the drug by the ion pair monomer. The polymers are applied to the selective extraction of glibenclamide from blood serum samples, achieving recoveries of up to 98% and demonstrating excellent long-term stability, negating the need for regular sorbent regeneration
Template and target information: glibenclamide, sulfonylureas

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