MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Pessagno F, Hasanah AN, Manesiotis P
Article Title: Molecularly imprinted 'traps' for sulfonylureas prepared using polymerisable ion pairs.
Publication date: 2018
Journal: RSC Advances
Volume: 8
Issue: (26)
Page numbers: 14212-14220.
DOI: 10.1039/C8RA01135D

Abstract: A novel approach towards recognition of sulfonylureas based on a polymerisable ion pair is presented. A solution association constant >10^5 M-1 between the model target glibenclamide and 4-vinylbenzyltrimethylammonium methacrylate is measured, and the formation of 1 : 1 complexes verified. Subsequently prepared stoichiometrically imprinted polymers exhibit exceptionally high affinity and binding capacity for glibenclamide, owing to synergistic binding of both the neutral and deprotonated form of the drug by the ion pair monomer. The polymers are applied to the selective extraction of glibenclamide from blood serum samples, achieving recoveries of up to 98% and demonstrating excellent long-term stability, negating the need for regular sorbent regeneration
Template and target information: glibenclamide, sulfonylureas


  I love MIPs mug  multi MIPs logo mug  British periodic table patriotic tote bag

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner