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Reference type: Book Chapter
Authors: Favetta P, Ayari MG, Agrofoglio LA
Publication date: 2018
Chapter title: Molecularly Imprinted Polymers-based Separation and Sensing of Nucleobases, Nucleosides, Nucleotides and Oligonucleotides.
Chapter number: 3
Page numbers: 65-123.
DOI: 10.1039/9781788010474-00065

Book title: Molecularly Imprinted Polymers for Analytical Chemistry Applications
Editors: Kutner W, Sharma PS
Publisher: Royal Society of Chemistry
ISBN: 978-1-78262-647-3

Abstract: Modified nucleosides have become cornerstones of treatment for patients with cancer or viral infections. Moreover, they are excreted in the urine of cancer patients in high levels and are considered to be potential tumor biomarkers. ATP and its analogues play an important role in several functions of the cardiovascular system. Moreover, circulating nucleotides have therapeutic importance on the progression of metabolic disorders. Thus, their detection and quantization are important. To gain in selectivity, the design of artificial polymer receptors, so-called molecularly imprinted polymers (MIPs) that can selectively recognize nucleotide bases, has gained importance from the theoretical application point of view. We will initially review the articles that are interested in the development of MIPs for the recognition of nucleoside analogues. Then, the second part of the chapter will describe the work published on the use of MIPs in the field of separation techniques and sample pretreatment. The final part will summarize research where the MIP technology can improve the analytical selectivity of the sensors of all types.
Template and target information: Review - MIPs for nucleotides, nucleosides etc.


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