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Reference type: Journal
Authors: Li SH, Li JP, Luo JH, Xu Z, Ma XH
Article Title: A microfluidic chip containing a molecularly imprinted polymer and a DNA aptamer for voltammetric determination of carbofuran.
Publication date: 2018
Journal: Microchimica Acta
Volume: 185
Issue: (6)
Page numbers: ArticleNo295.
DOI: 10.1007/s00604-018-2835-1

Abstract: An electrochemical microfluidic chip is described for the determination of the insecticide carbofuran. It is making use of a molecularly imprinted film (MIP) and a DNA aptamer as dual recognition units. The analyte (carbofuran) is transported to the MIP and captured at the identification site in the channel. Then, carbofuran is eluted with carbinol-acetic acid and transported to the DNA aptamer on the testing position of the chip. It is captured again, this time by the aptamer, and detected by differential pulse voltammetry (DPV). The dual recognition (by aptamer and MIP) results in outstanding selectivity. Additionally, graphene oxide-supported gold nanoparticles (GO-AuNPs) were used to improve the sensitivity of electrochemical detector. DPV response is linear in the 0.2 to 50 nM carbofuran concentration range at a potential of -1.2 V, with a 67 pM detection limit. The method has attractive features such as its potential for high throughput, high degree of automation, and high integration. Conceivably, the method may be extended to other analytes for which appropriate MIPs and aptamers are available
Template and target information: carbofuran
Author keywords: X-ray photoelectron spectroscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectra, differential pulse voltammetry, Ultraviolet-visible absorption spectroscopy, polydimethylsiloxane, Graphene oxide, gold nanoparticles, Pesticide residues

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