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Reference type: Journal
Authors: Yuan XH, Zhao Y, Liao XG
Article Title: Optimization of Preparation Technique of Valsartan Molecularly Imprinted Polymer by Orthogonal Experiment.
Publication date: 2013
Journal: Traditional Chinese Drug Research and Clinical Pharmacology
Issue: (4)
Page numbers: 420-423.
Alternative URL: http://caod.oriprobe.com/articles/46209202/Optimization_of_Preparation_Technique_of_Valsartan_Molecularly_Imprint.htm

Abstract: Objective To optimize the conditions for synthesizing the molecularly imprinted polymer (MIP) of valsartan (Val-MIP). Methods With binding ratio and Val-MIP polymer hardness as the evaluation indexes, the preparation conditions of the Val-MIP were optimized by orthogonal experiment. Results The optimal preparation conditions for Val-MIP was as follows: the ratio of Valsartan to 2-VPY being 1:4,ratio of 2-VPY to EDMA being 1:2.5, and the ratio of Valsartan and 2-VPY to AIBN being 1:10. Conclusion The Val-MIP polymer synthesized by the optimized preparation technology has good adsorption performance and appropriate hardness.
Template and target information: valsartan, Val
Author keywords: Valsartan, molecularly imprinted polymer, Orthogonal design, synthesis conditions

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