Abstract: A xanthine (XA) molecularly imprinted polymers (MIPs) were directly prepared on carbon fiber microelectrode (CFME), using pyrrole as function matrix, and xanthine as template molecule by cyclic voltammetry. The response performances of the electrochemical microsensor based on the prepared MIPs were investigated. The MIPs catalyzed the oxidation of XA on CFME which exhibit one electron reaction. Good affinity and excellent specific recognization to xanthine were observed from thermodynamic and kinetic adsorption experiments, and a kinetic constant of 0.24 shows a faster response to xanthine on MIPs/CFME compared to MIPs/GCE (0.71). An Imprinting factor of 14.1 were calculated out by isothermal curve fitting data on MIPs/CFME which is much higher than the recognization of the common coexistence and structural similarities, and shows a good imprinting effect closing to MIPs/GCE (9.0). Two linear response of oxidation peak current of xanthine to concentration were obtained, which ranges from 4.0-60 μmol L-1 and 0.08-2.0mmol L-1 with a detection limit of 0.25μmol L-1.
Template and target information: xanthine, XA
Author keywords: Molecularly imprinted polymers, Electrochemical sensor, xanthine, Pyrrole, response performance, absorption performance