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Abstract: The (anaphylactoid) hypersensibility mechanism of "imprinting templates" characteristics of traditional Chinese medicine (TCM) injection supramolecules was clarified to lay the foundation to build safety evaluation method. Based on the previous publication on special impact of Chinese medicine theories on supramolcular chemistry,combined with the natural origination of (anaphylactoid) hypersensitized special rules as well as the sensitization phenomenon of cordate houttuynia injection, the impact of the structure characteristics of "imprinting templates" in TCM injection supramolecules on its (anaphylactoid) hypersensibility was clarified. In Chinese medicine injections, the supramolecular structures can independently be generated, showing overall apparent (anaphylactoid) hypersensibility nature, and their structure characteristics were dependent on the strength. In addition, (anaphylactoid) hypersensitive critical supramolecular structure was present. When it was administrated by "injection", it's structure was not easy to be destroyed, often showing apparent immunogenicity, whereas if it was administrated by "oral", the structure would be destroyed by the gastrointestinal tract, showing weaker or no apparent immunogenicity. Therefore,there are differences in (anaphylactoid) hypersensibility between "injection" and "oral" administration of TCM. TCM injections would produce the supramolecules between "molecular society" by independent reaction of supramolecular "imprinting template" (chemical determinants), showing apparent immune process of recognition, copying, and storage. Single molecule is a special example for this. The screening of anaphylactoid (sensitinogen) includes the single ingredients and their forming supramolecules for TCM injection. This is the unique feature for safety evaluation of Chinese medicine injection.
Author keywords: Chinese medicine injection, safety, supramolecular (toxicology) pharmacology, Supramolecules, imprinting template, molecular society