MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Tao YQ, Tang WH, Liu JL, Deng KW, He FY, Zhou YQ
Article Title: Solubilization characteristics of licorice based on supramolecular "imprinted template" theory.
Publication date: 2016
Journal: China Journal of Chinese Materia Medica
Volume: 41
Issue: (10)
Page numbers: 1849-1854.
Alternative URL: http://caod.oriprobe.com/articles/50230298/Solubilization_characteristics_of_licorice_based_on_supramolecular__im.htm

Abstract: To investigate the effect of the ingredient group of traditional Chinese medicine (TCM) with different "imprinted template" on the supramolecular solubilization ability of licorice, in order to lay a theoretical foundation for explaining the solubilization phenomenon of the components of TCM. Based on the independent supramolecular "imprinted template" rules, molecular connectivity index (MCI) and the correlation of n-octanol-water partition coefficient (log P) were used to indicate hydrophilic lipophilic capacity of TCM, and the extractum rate was used to indicate the solubilization effect of licorice on single TCM herbs or compounds. The solubilization ability of licorice was evaluated based on MCI, log P and the extractum rate. According to the results, the correlation coefficient between MCI and log P for single herbs was 0.942, and that for single herb adding licorice was 0.916. The extractum rate of most herbs was increased after adding licorice. The correlation coefficient among the extractum rate as well as MCI and log P change values before and after adding licorice were respectively 0.837, 0.405. The correlation coefficient between MCI and log P for eight compounds was 0.937. Meanwhile, licorice had a solubilization effect on the remaining 7 compound except for Huangqi decoction. Therefore, licorice shows the solubilization effect through the independent supramolecular "imprinted template", so as to improve the hydrophilic lipophilic ability. There was a high positive correlation between the MCI and log P in ingredients for TCM, which could be used as important parameters to indicate the "imprinted template" feature for components of TCM. The study on the solubilizing effect of TCM with the supramolecular "imprinted template" theory was feasible, and will lay a foundation for the reform of single-herb dosage form.
Author keywords: licorice, traditional Chinese medicine compound, n-octanol-water partition coeffieient, molecular connectivity index, supramolecular, imprinted template, Micelle, reform of single dosage form


  mipdatabase.com logo imprinters do it in bulk shirt  Science Teacher peptide mug  Perpetual student shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner