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Reference type: Journal
Authors: Xia WQ, Huang J, Wang GN, Liu J, Wang JP
Article Title: Molecularly imprinted polymer based microtiter chemiluminescence array for determination of phenothiazines and benzodiazepines in pork.
Publication date: 2018
Journal: Analytical Biochemistry
Volume: 554
Page numbers: 9-15.
DOI: 10.1016/j.ab.2018.05.021
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0003269718304147

Abstract: In this study, a molecularly imprinted polymer based chemiluminescence array capable of simultaneous determining phenothiazines and benzodiazepines was first reported. Two polymers were coated in different wells of the conventional 96-well microtiter plate as the recognition reagents, and the added analytes competed with a horseradish peroxidase-labeled bi-hapten conjugate to bind the recognition reagents. The light signal was induced by using a highly effective luminol-H2O2-IMP system. The assay procedure consisted of only one sample-loading step prior to data acquisition. Then, the array was used to determine 4 phenothiazines and 5 benzodiazepines in pork simultaneously. The limits of detection for the 9 drugs were in a range of 0.001-0.01 ng/mL, and the recoveries from the fortified blank pork were in a range of 63.5%-94.1%. Furthermore, the array could be reused for 8 times. The detection results for some real pork samples were consistent with an ultra performance liquid chromatography method
Template and target information: phenothiazines, benzodiazepines
Author keywords: Phenothiazines, Benzodiazepines, molecularly imprinted polymer, Chemiluminescence array, Pork


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