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Abstract: A simple, rapid and sensitive electrochemical method using a molecularly imprinted polymer (MIP) based on the electropolymerisation of pyrrole (Py) was developed for the determination of 2-isopropoxyphenol (IPP) in model and real samples. The electrochemical behavior of IPP was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) on bare glassy carbon (GC) electrodes in a Britton-Robinson buffer (pH, 2) solution. IPP exhibited a quasi-reversible behavior on a GC electrode. An anodic peak for IPP showed good linearity over a concentration range from 0.21 to 75 μM (r2 = 0.999) with a limit of detection (LOD) of 0.21 μM in DPV. For the theoretical design of the MIP, to screen suitable functional monomers and to optimize monomer-template mole ratio, a computational approach was followed using density functional (B3LYP) and Semi-Empirical Parameterized Model number 3 (PM3) models. Pyrrole monomers in the presence of IPP template were electrochemically polymerized using CV on the working electrode. The sensor exhibited an oxidation peak at 0.737V and an excellent linearity (r2 = 0.9969) toward increasing concentration of the template over the range 0.09 - 45 μM with a LOD of 0.09 μM. Intra- and inter-day assay precisions, expressed as %RSD, were overall less than 8.67% for both methods. The result of the selectivity experiment showed that the imprinted sensor has a good response and selectivity toward IPP. The developed sensors were successfully applied for the determination of IPP in real samples recovered from in vitro metabolism of Propoxur (PPX)
Template and target information: 2-isopropoxyphenol, IPP
Author keywords: 2-Isopropoxyphenol, molecularly imprinted polymer, Computational chemistry, cyclic voltammetry, differential pulse voltammetry