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Abstract: Four molecular imprinted polymer (MIP) membranes for Mebeverine.HCl (MBV.HCl) were prepared based on PVC matrix. The imprinted polymers were prepared by polymerization of 2-acrylamido-2-methyl-1-propane sulphonic acid (AMPS) as monomer, pentaerythritoltriacrylate (PETRA) as a cross linker ,benzoyl peroxide (BPO) as an initiator and mebeverine as a template. Four different types of plasticizers of different viscosities were used and the electrodes were fully characterized in terms of plasticizer type, response time, lifetime, pH and detection limit. The MBV-MIP electrodes exhibited Nernstian response in concentration range from 1.0 x 10-6 to1.0 x 10-1 M with slopes of 13.98, 19.60, -20.43 and 19.01 mV/ decade. The detection limit and quantification are found to be 4 x 10-6, 3 x 10-6, 2 x 10-5and 1.2 x 10-6 M ,respectively. Interference study for inorganic cations and amino acids was also studied. The best electrode based tris (2-ethyl hexyl) phosphate plasticizer was applied successfully for potentiometric determination of mebeverine in commercial tablets. Excellent average recovery obtained by potentiometric methods was about 102.26% which is in good agreements with British Pharmacopoeia.
Template and target information: mebeverine hydrochloride, MBV.HCl
Author keywords: Molecularly imprinted electrodes, Mebeverine hydrochloride, potentiometric method, 2-Acrylamido-2-methyl-1-propane sulphonic acid monomer