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Reference type: Journal
Authors: Toloza CAT, Almeida JMS, Khan S, dos Santos YG, da Silva AR, Romani EC, Larrude DG, Freire FL, Aucélio RQ
Article Title: Gold nanoparticles coupled with graphene quantum dots in organized medium to quantify aminoglycoside anti-biotics in yellow fever vaccine after solid phase extraction using a selective imprinted polymer.
Publication date: 2018
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 158
Page numbers: 480-493.
DOI: 10.1016/j.jpba.2018.05.050
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0731708518306320

Abstract: The determination of kanamycin sulfate was made indirectly by measuring its effect on photoluminescent amino functionalized graphene quantum dots (GQDs-amino) associated with gold nanoparticles (AuNPs) that were produced by the reduction of AuCl4 with NaBH4 in an aqueous dispersion of GQDs-amino (obtained by the pyrolysis of citric acid and glutathione) also containing the cationic surfactant CTAB. The AuNPs-GQDs-amino-CTAB system presents a suppressed photoluminescence that is amplified in the presence of kanamycin. Under optimized experimental conditions, the photoluminescence amplification of the nanomaterial system showed a linear response as a function of kanamycin concentration, covering three orders of magnitude (10-7 to 10-5 mol L-1). The use of solid phase extraction with a cartridge packed with aminoglycoside selective molecularly imprinted polymer ensured selectivity in determinations made on yellow-fever vaccine and veterinary pharmaceutical formulations. The analytical results were statistically similar to those obtained with an HPLC-based fluorescence method (after chemical derivatization). The proposed method is a simple, sensitive and selective approach that does not involve the use of toxic reagents employed for chemical derivatization of aminoglycoside antibiotics
Template and target information: kanamycin sulfate
Author keywords: Amino-functionalized graphene quantum dots, gold nanoparticles, Organized medium, Photoluminescence on, off, Kanamycin sulfate

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