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Reference type: Journal
Authors: Chen LZ, Wang RY, Cui L, Wang X, Wang LL, Song FY, Ji WH
Article Title: Preparation of five high-purity iridoid glycosides from Gardenia jasminoides Eills by molecularly imprinted solid-phase extraction integrated with preparative liquid chromatography.
Publication date: 2018
Journal: Journal of Separation Science
Volume: 41
Issue: (13)
Page numbers: 2759-2766.
DOI: 10.1002/jssc.201800086

Abstract: Five iridoid glycosides were prepared using molecularly imprinted solid-phase extraction combined with preparative high-performance liquid chromatography. Hydrophilic molecularly imprinted polymers were synthesized using α-1-allyl-2-N-acetyl glucosamine, which introduced an abundance of hydrophilic groups into the polymers. Using molecularly imprinted solid-phase extraction as the sample pretreatment procedure, five iridoid glycosides, gardenoside, geniposide, shanzhiside, geniposidic acid, and genipin-1-O-gentiobioside, were selectively enriched from Gardenia fructus extracts. Preparative high-performance liquid chromatography then provided iridoid glycosides with a purity >98%. The structures were elucidated by using nuclear magnetic resonance spectroscopy, optical rotation and melting point measurements, and mass spectrometry. The results demonstrate that molecularly imprinted solid-phase extraction combined with preparative high-performance liquid chromatography was an efficient, rapid, and economical method for the preparation of bioactive compounds from natural products
Template and target information: iridoid glycosides, gardenoside, geniposide, shanzhiside, geniposidic acid, genipin-1-O-gentiobioside
Author keywords: Gardenia jasminoides Eills, Iridoid glycosides, molecular imprinted polymers, preparative liquid chromatography, Solid-phase extraction


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