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Reference type: Journal
Authors: Gennaro A, Yongabi D, Deschaume O, Bartic C, Wagner P, Wübbenhorst M
Article Title: Cell detection by surface imprinted polymers (SIPs) - A study of the sensor surface by optical and dielectric relaxation spectroscopy.
Publication date: 2018
Journal: IEEE Transactions on Dielectrics and Electrical Insulation
Volume: 25
Issue: (3)
Page numbers: 816-821.
DOI: 10.1109/TDEI.2018.007092
Alternative URL: https://ieeexplore.ieee.org/document/8410708/

Abstract: Cell imprinting on polymer layers produces synthetic receptors, so called surface imprinted polymers (SIPs) that are suitable for specific and selective cellular recognition. However, their recognition mechanisms are not yet fully understood. Therefore, various factors that influence cell recognition were explored using different spectroscopic techniques. Specifically, the molecular dynamics of surface-imprinted and non-imprinted polyurethane layers was studied with focus on the dielectric relaxation signatures of proteins and lipids by dielectric relaxation spectroscopy. Furthermore, we have tested an interdigitated comb electrode (IDE) structure placed beneath the cell recognition layer. It was shown that both plane and IDE configurations sense the molecular dynamics of the PU layer correctly, and also reveal specific information about the polymer/cell interface
Template and target information: cells
Author keywords: Cavity resonators, Dielectrics, Lipidomics, Plastics, spectroscopy, Surface morphology, surface topography, IDEs, cell detection, dielectric relaxation spectroscopy, Membrane proteins, Phospholipids, polyurethane, Surface-imprinted polymers

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