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Abstract: Molecularly imprinted polymers (MIPs) in bead form were prepared by seed swelling and suspension polymerization with trimethylolpropane trimethacrylate (TRIM) as crosslinker and tyrosine as template. The appearance of the beads was found to be greatly influenced by the concentration of polyvinyl alcohol (PVA) used as dispersant and the ratio of water to TRIM (W/T) during polymerization. When W/T was 46:1 (V/V) and the concentration of PVA-water solution was 4.6 (%m/m), the result was more desirable size distribution with fewer misshapen beads. A series of imprinted polymers with methacrylic acid (MAA), acrylamide (AM), 2-vinylpyridine (VP) and 2-acrylamido- 2-methylpropanesulfonic acid (AMPS) as functional monomers (FM), respectively, were prepared, where the molar ratio of tyrosine, FM and TRIM was chosen as 1: 16:17. The molecule adsorbing and selecting analysis of the polymers showed that although all the imprinted polymers adsorbed the templates following the rule of Langmuir and exhibited an obvious molecule selecting capability compared with their control polymers (CP), the adsorbing constant and the separating factor were much different when the functional monomers varied. AMPS worked better than the other FM in the present work with a higher value of asymptotic maximum solid phase concentration (0.282 mol/kg), adsorbing constant (198.8 1/mol), and a larger separating factor (1.93) when phenylalanine was used as the competitive molecule
Template and target information: tyrosine