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Abstract: Simultaneous determination of three fluoroquinolones, ofloxacin, norfloxacin and ciprofloxacin residues in milk was accomplished by HPLC after multi-walled carbon nanotube molecular imprinting solid-phase extraction column with enrofloxacin as dummy template. The milk samples were precipitated with sodium carbonate and acetonitrile,and then adjusted to p H 3.0 with sodium acetatehydrochloric acid system. After purification by self-made multi-walled carbon nanotubes molecularly imprinted polymers solid-phase extraction (MWCNTs-MISPE),the content of ofloxacin,norfloxacin and ciprofloxacin were determined by high performance liquid chromatography (HPLC). The calibration curves of three compounds were linear in the range of 20.00-1000 ng/m L (r 0.9998),with the recoveries of 82.3%-99.4% at three loading levels,and the intra-day and inter-day precision were less than 20%. The fluoroquinolones in milk (n = 3) were detected to be lower than the EU standards. This work is the first application of MWCNTs-MISPE column to purify and concentrate fluoroquinolones in milk. This method is simple and effective with high sensitivity,and can be used for the detection of ofloxacin,norfloxacin and ciprofloxacin in milk.
Template and target information: dummy template, enrofloxacin, fluoroquinolones, ofloxacin, norfloxacin, ciprofloxacin