MIPdatabase
Authors: Al-Safi AJ, Al-Bayati YK
Article Title: Synthesis and Characterization of Molecularly Imprinted Polymer for Tramadol Hcl Using Acryl Amide and 2-Hydroxyethyl Meth Acrylate as Monomers.
Publication date: 2018
Journal: Current Issues in Pharmacy and Medical Sciences
Volume: 31
Issue: (2)
Page numbers: 81-88.
DOI: 10.1515/cipms-2018-0016
Alternative URL: https://content.sciendo.com/view/journals/cipms/31/2/article-p81.xml
Abstract: Four electrodes were synthesized based on molecularly imprinted polymers (MIPs). Two MIPs were prepared by using tramadol hydrochloride (TRH) as the template, acryl amide (AA) and 2-hydroxy ethyl meth acrylate (2-HEMA) as monomers, divinyl benzene as a cross linker, and benzoyl peroxide as initiator, respectively. The same composition was used to prepare non-imprinted polymers (NIPs), but without the template (Tramadol hydrochloride). Different plasticizers were employed to prepare the membranes; tris (ethyl hexyl) phosphate (TEHP), tri Butyl phosphate (TBP), di-octyl phthalate (DOP) and nitrobenzene (NB) in PVC matrix. The electrode characteristics and properties were studied, including: slope, detection limit, life time and linearity range. The results of selectivity coefficient measurements using amino acids as interfering species showed no effect on tramadol electrode response. The prepared electrodes were intended for use in determining tramadol in pharmaceutical samples
Template and target information: tramadol.HCl, tramadol
Author keywords: Molecularly imprinted electrodes, tramadol hydrochloride, potentiometric method, 2-HEMA, AA monomers
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