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Reference type: Journal
Authors: Huang J, Tong JX, Luo J, Zhu Y, Gu Y, Liu XY
Article Title: Green Synthesis of Water-Compatible Fluorescent Molecularly Imprinted Polymeric Nanoparticles for Efficient Detection of Paracetamol.
Publication date: 2018
Journal: ACS Sustainable Chemistry & Engineering
Volume: 6
Issue: (8)
Page numbers: 9760-9770.
DOI: 10.1021/acssuschemeng.8b00823

Abstract: In this work, one-pot green synthesis of a novel kind of water-compatible fluorescent molecularly imprinted polymer nanoparticle for selective optosensing of paracetamol was developed via macromolecular assembly of an amphiphilic fluorescent copolymer and in situ photo-cross-linking. Amphiphilic photo-cross-linkable and fluorescent copolymers containing carbazole groups were synthesized and could coassemble with paracetamol (PCM, template molecule) and photoinitiator in aqueous solution. The obtained photo-cross-linkable fluorescent nanoparticles were then cross-linked triggered by UV-irradiation, generating the hydrophilic and fluorescent molecularly imprinted polymer nanoparticles (FMIP nanoparticles) in aqueous media. The whole procedure was carried out at mild working condition, which is facile, green, and energy-saving. The resulting FMIP nanoparticles showed high selectivity toward PCM and obvious fluorescence quenching, induced by template-binding, in water and were a kind of efficient fluorescent chemosensor for the sensing of PCM. A wide linear range over PCM concentration from 4 to 1000 μM with a detection limit of 1.0 μM has been demonstrated using FMIP nanoparticles as chemosensor. Moreover, a rapid response of less than 2 min has been demonstrated. Finally, such a chemosensor based on FMIP nanoparticles was also successfully employed for the detection of PCM in commercial PCM tablets as well as urine samples
Template and target information: paracetamol, acetaminophen
Author keywords: Fluorescent molecularly imprinting, nanoparticles, paracetamol sensing, self-assembly

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