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Reference type: Journal
Authors: Abdallah NA, Ibrahim HF
Article Title: Potentiometric sensor of graphene oxide decorated with silver nanoparticles/molecularly imprinted polymer for determination of gabapentin.
Publication date: 2018
Journal: Carbon Letters
Volume: 27
Issue: (1)
Page numbers: 50-63.
DOI: 10.5714/CL.2018.27.050
Alternative URL: http://carbonlett.org/PublishedPaper/year_abstract.asp?idx=691

Abstract: An imprinted potentiometric sensor was developed for direct and selective determination of gabapentin. Sensor is based on carbon paste electrode adapted by graphene oxide that is decorated with silver nanoparticles and mixed with molecularly imprinted polymers nanoparticles using gabapentin as a template molecule. The synthesized nanoparticles were characterized by Fourier transmission infrared spectroscopy, transmission electron microscopy and X-ray diffraction. Under optimal experimental conditions, the studied sensor exhibited high selectivity and sensitivity with LOD of 4.8 x 10-11 mol L-1. It provided a wide linearity range from 1 x 10-10 to 1 x 10-3 mol L-1 and high stability for more than 3 mo. The sensor was effectively used for the determination of gabapentin in pharmaceutical tablets and spiked plasma samples.
Template and target information: gabapentin
Author keywords: gabapentin, molecular imprinted nanoparticles, Graphene oxide, sensor


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