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ISBN: 978-3-9816876-9-9
Volume number: P-1 - Sensors for Diagnostics and Healthcare
Conference information: Proceedings, 17th International Meeting on Chemical Sensors - IMCS 2018

Abstract: This paper describes a novel strategy to fabricate a low-cost microfluidic paper-based analytical device (μPAD) readily based on surface molecularly imprinted technology for clinical detection of carcino-embryonic antigen (CEA). The movable valve fabrication was realized using hollow rivets as the holding center to control the electrode and channel of the μPAD in different layer movement, so the entire process of synthesis and testing could be completed easily. Graphene oxide, chitosan and CEA templates were assembled on the μPAD as a substrate, and subsequently the molecularly imprinted membranes were formed by electropolymerization of dopamine. Finally, the novel μPAD was obtained after removal of CEA templates. Because the entire manufacturing process was done on the μPAD without any external treatment, the μPAD has the characteristics of easy synthesis, low cost and low toxicity. Moreover, the μPAD gave a flexible and easy way to operate the entire detection process conveniently. Experimental parameters such as equilibration time, scan cycles, template concentration and pH value were optimized. A good linearity was obtained in the range of 1 500 ng mL-1 (R2= 0.994) with the limit of detection (LOD) of 0.21 ng mL-1.
Template and target information: protein, carcino-embryonic antigen, CEA