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Reference type: Journal
Authors: Tuwahatu CA, Yeung CC, Lam YW, Roy VAL
Article Title: The molecularly imprinted polymer essentials: curation of anticancer, ophthalmic, and projected gene therapy drug delivery systems.
Publication date: 2018
Journal: Journal of Controlled Release
Volume: 287
Page numbers: 24-34.
DOI: 10.1016/j.jconrel.2018.08.023
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0168365918304899

Abstract: The development of polymeric materials as drug delivery systems has advanced from systems that rely on classical passive targeting to carriers that can sustain the precisely controlled release of payloads upon physicochemical triggers in desired microenvironment. Molecularly imprinted polymers (MIP), materials designed to capture specific molecules based on their molecular shape and charge distribution, are attractive candidates for fulfilling these purposes. In particular, drug-imprinted polymers coupled with active targeting mechanisms have been explored as potential drug delivery systems. In this review, we have curated important recent efforts in the development of drug-imprinted polymers in a variety of clinical applications, especially oncology and ophthalmology. MIP possesses properties that may complement the traditional delivery systems of these two disciplines, such as passive enhanced permeability and retention effect (EPR) in cancer tumors, and passive drug diffusion in delivering ophthalmic therapeutics. Furthermore, the prospects of MIP integration with the emerging gene therapies will be discussed
Template and target information: Review - MIPs in drug delivery
Author keywords: imprinting, cancer, Ophthalmic, Gene therapy, sustained release, drug delivery

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