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Reference type: Journal
Authors: El-Wekil MM, Mahmoud AM, Marzouk AA, Alkahtani SA, Ali R
Article Title: A novel molecularly imprinted sensing platform based on MWCNTs/AuNPs decorated 3D starfish like hollow nickel skeleton as a highly conductive nanocomposite for selective and ultrasensitive analysis of a novel pan-genotypic inhibitor velpatasvir in body fluids.
Publication date: 2018
Journal: Journal of Molecular Liquids
Volume: 271
Page numbers: 105-111.
DOI: 10.1016/j.molliq.2018.08.105
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0167732218327600

Abstract: Herein, a novel ultrasensitive molecularly imprinted sensor (MIS) for selective determination of a new direct acting anti-HCV velpatasvir (VELPR) was developed and fabricated for the first time. The fabricated MIS based on modification of a glassy carbon electrode (GCE) with multi-walled carbon nanotubes-gold nanoparticles (MWCNTs-AuNPs) composite after deposition on electro-synthesized 3D starfish like hollow nickel skeleton (3D SH-Ni S) to increase conductivity and effective surface area of MIS to amplify its signal. After that, the electrode was coated with molecularly imprinted polymer (MIP) by in situ electro-polymerization forming cavity with specific affinity and natural binding sites to VELPR. Differential pulse voltammetry (DPV) was used for selective detection of VELPR in complex matrices whereas, scanning electron microscope (SEM) and cyclic voltammetry (CV) were employed to characterize the fabricated sensor. All experimental factors concerning fabrication and chemical sensing properties were carefully studied and optimized. Under the optimized variables, the fabricated sensor exhibited excellent DPV response to VELPR over the range of 0.649-80.0 ng mL-1 with LOD of 0.21 ng mL-1. In addition to high sensitivity and selectivity, the sensor response to VELPR was highly reproducible and stable. Moreover, the fabricated sensor was successfully applied for the determination of VELPR in complex biological matrices and pharmaceutical tablets
Template and target information: velpatasivir, VELPR
Author keywords: Electrochemical sensor, molecularly imprinted polymer, Velpatasivir, Starfish like hollow nickel skeleton, Multi-walled carbon nanotubes-gold nanocomposite, biological fluids

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