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Abstract: Polymer films that are selective toward optical isomers such as cinchonidine and cinchonine were prepared by using molecular imprinting technique, and were used as an additional part of the sensor chip of the Surface Plasmon Resonance (SPR) sensor. For the preparation of the cinchonidine-selective films, cinchonidine was used as a template; methacrylic acid, as a functional monomer; ethyleneglycol dimethacrylate, as a crosslinking monomer; and 2,2'-azobisisobutyronitrile, as an initiator. Polymerization was carried out with the use of UV light irradiation to form polymer films, which were finally washed with a mixture solution of methanol and acetic acid. With the use of the sensor chip immobilizing the cinchonidine-selective film, various concentration of cinchonidine aqueous solutions were measured to obtain the rate at which cinchonidine was caught by the cinchonidine-selective film. The rate increased linearly with increasing the concentration. The cinchonidine-selective film was selective toward cinchonidine against cinchonine; or vice versa.
Template and target information: cinchonidine