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Reference type: Journal
Authors: Zarezadeh A, Rajabi HR, Sheydaei O, Khajehsharifi H
Article Title: Application of a nano-structured molecularly imprinted polymer as an efficient modifier for the design of captopril drug selective sensor: Mechanism study and quantitative determination.
Publication date: 2019
Journal: Materials Science and Engineering: C
Volume: 94
Page numbers: 879-885.
DOI: 10.1016/j.msec.2018.10.042
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0928493117348804

Abstract: In the present study, electrochemical studies and potentiometric determination of captopril (CAP) drug were presented using a glassy carbon electrode (GCE) and carbon paste electrode (CPE), respectively; which is modified with a synthetic nano-structured molecularly imprinted polymer (MIP). CAP-MIP sample with an average particle size of 95 nm was synthesized using a precipitation polymerization method. The electrochemical behavior of CAP was studied on a MIP modified GCE, in an aqueous solution at pH 3.0. The electron transfer coefficient (α) was determined for the CAP drug, using electrochemical approaches. The prepared CAP-MIP was also used as a modifier in a CPE to design a selective CAP sensor, before its potentiometric determination. The modified CPE exhibits a good electrochemical response with a Nernstian slope of 59.15 1.5 mV per decade over a wide linearity in the concentration range of 3.0 x 10-9 - 1.0 x 10-1 mol L-1. The cyclic voltammetry results were in good agreement with the electrochemical studies for the 1H+/1e- process. The designed electrode indicates a reasonable selectivity for CAP over other studied drugs such as ibuprofen, paracetamol, acyclovir, pyrazinamide, dimenhydrinate, and naproxen as well as with an excellent applicability in some pharmaceutical products
Template and target information: captopril, CAP
Author keywords: cyclic voltammetry, Imprinted polymeric nanostructures, Potentiometry, sensors

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