MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Fatma S, Prasad BB, Singh K, Singh R, Jaiswal S
Article Title: A reduced graphene oxide ceramic electrode modified with one MoNomer doubly imprinted acryloylated tetraamine cobalt phthalocyanine polymer for the simultaneous analysis of anticancerous drugs.
Publication date: 2019
Journal: Sensors and Actuators B: Chemical
Volume: 281
Page numbers: 139-149.
DOI: 10.1016/j.snb.2018.10.070
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400518318331

Abstract: The present work illustrates a novel technique for the development of One MoNomer dual imprinted polymer, utilizing acryloylated tetraamine cobalt phthalocyanine as a tetrafunctional monomer, on the surface of a reduced graphene oxide ceramic electrode. This electrode was used for the simultaneous analysis of a mixture of anticancerous drugs, chlorambucil and dacarbazine, at ultra-trace level in real samples. The acryloylated tetraamine cobalt phthalocyanine was typically selected in this work for polymerization because it served both as a monomer and a crosslinker, with higher electroconductivity. The detection sensitivity of the measurement was realized to be 0.041 ng mL-1 and 0.017 ng mL-1 for chlorambucil and dacarbazine, respectively in the aqueous environment. The complex matrices of blood plasma, urine and pharmaceutics were examined which yielded the validated results without any effects of matrix complications including cross-reactivity, and false-positives. The therapeutic ranges of the test analyte(s) (chlorambucil 0.159-28.524 ng mL-1, dacarbazine 0.063-37.286 ng mL-1) were realized to be larger demonstrating perfect linearity (R2 = 0.99) with the improved voltammetric response. This work merits special significance to decide the adequate supplementation of drug(s) in combined therapy for cancer treatment
Template and target information: dual template, chlorambucil, dacarbazine
Author keywords: One MoNomer molecularly imprinted polymer, Dual imprinting, Chlorambucil, Dacarbazine, Real samples

  Periodic table Coach hat  Peptide peptide mug  We need to talk about Kelvin shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner