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Abstract: The present work illustrates a novel technique for the development of One MoNomer dual imprinted polymer, utilizing acryloylated tetraamine cobalt phthalocyanine as a tetrafunctional monomer, on the surface of a reduced graphene oxide ceramic electrode. This electrode was used for the simultaneous analysis of a mixture of anticancerous drugs, chlorambucil and dacarbazine, at ultra-trace level in real samples. The acryloylated tetraamine cobalt phthalocyanine was typically selected in this work for polymerization because it served both as a monomer and a crosslinker, with higher electroconductivity. The detection sensitivity of the measurement was realized to be 0.041 ng mL-1 and 0.017 ng mL-1 for chlorambucil and dacarbazine, respectively in the aqueous environment. The complex matrices of blood plasma, urine and pharmaceutics were examined which yielded the validated results without any effects of matrix complications including cross-reactivity, and false-positives. The therapeutic ranges of the test analyte(s) (chlorambucil 0.159-28.524 ng mL-1, dacarbazine 0.063-37.286 ng mL-1) were realized to be larger demonstrating perfect linearity (R2 = 0.99) with the improved voltammetric response. This work merits special significance to decide the adequate supplementation of drug(s) in combined therapy for cancer treatment
Template and target information: dual template, chlorambucil, dacarbazine
Author keywords: One MoNomer molecularly imprinted polymer, Dual imprinting, Chlorambucil, Dacarbazine, Real samples