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Reference type: Journal
Authors: Shariati R, Rezaei B, Jamei HR, Ensafi AA
Article Title: Application of coated green source carbon dots with silica molecularly imprinted polymers as a fluorescence probe for selective and sensitive determination of phenobarbital.
Publication date: 2019
Journal: Talanta
Volume: 194
Page numbers: 143-149.
DOI: 10.1016/j.talanta.2018.09.069
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0039914018309792

Abstract: Herein, a selective and sensitive fluorescence sensor was developed for the detection of phenobarbital, an epilepsy drug, using molecularly imprinted polymers (MIPs) coated on the surface of green source carbon dots (GSCDs). First, GSCDs were synthesized through a hydrothermal method using Cedrus as a carbon source. Then, a MIPs-GSCDs as a fluorescence probe was obtained by coating a thin film of silica on the surface of the GSCDs using a reverse micro emulsion method. In this step, phenobarbital, 3-aminopropyltriethoxysilane (APTES) and tetraethoxysilane (TEOS) were applied as a template, a functional monomer, and cross linker, respectively. The fluorescence signal of MIPs-GSCDs was selectively quenched by phenobarbital rebinding with MIP cavities. The fluorescence quenching signal was applied for phenobarbital sensing at the pH = 8 without the interference of other materials. After optimizing the factors affecting the sensor's response, a linear range between 0.4 and 34.5 nmol L-1 with a detection limit of 0.1 nmol L-1 was obtained. The sensor's capability in the real sample analysis was investigated by phenobarbital determination in a human blood plasma samples
Template and target information: phenobarbital
Author keywords: Fluorescence sensor, Green source carbon dot, Molecularly imprinted polymers, Cedrus, phenobarbital

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