MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Cai JT, Chen T, Xu YH, Wei S, Huang WG, Liu R, Liu JQ
Article Title: A versatile signal-enhanced ECL sensing platform based on molecular imprinting technique via PET-RAFT cross-linking polymerization using bifunctional ruthenium complex as both catalyst and sensing probes.
Publication date: 2019
Journal: Biosensors and Bioelectronics
Volume: 124-125
Page numbers: 15-24.
DOI: 10.1016/j.bios.2018.09.083
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566318307802

Abstract: Molecularly imprinted technique (MIT) has proven to be a significant tool in the analyzing area in virtue of its obvious advantages such as specific recognition, favorable stability to high temperature and higher sensitivity. Electrochemiluminescence (ECL) technology has also been receiving enormous attention as a powerful tool in sensing fields. However, sensors based on the combination of MIT and ECL technologies have seldom been reported yet. Herein, we find that Ru(bpy)32+ cannot only work as an efficient catalyst for photo-induced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization, but also as a sensing probe for ECL sensor. Based on this, we successfully construct ECL sensors via the combination of MIT and ECL techniques. In details, poly(methacrylic acid) (PMAA) and cross-linked PMAA were synthesized first via a well-controlled PET-RAFT polymerization using Ru(bpy)32+ as catalyst under illumination of visible light with a wavelength of 460 nm, as confirmed by 1H NMR and gel permeation chromatography (GPC). Then, negatively-charged Au nanoparticles (AuNPs) with average sizes of 20 nm were prepared and modified with Ru(bpy)32+ via electrostatic incorporation. MIPs were prepared on the surface of AuNPs using melamine (MEL) as the template via PET-RAFT controlled cross-linking polymerization. The MIPs modified AuNPs (AuNPs-MIPs) were then fixed on the surface of working electrode with Nafion to achieve a solid-state ECL sensing platform employing Ru(bpy)32+ as the ECL probes. The as-prepared sensor showed a wide detection range of 5.0 x 10-13 - 5.0 x 10-6 mol/L and a low detection limit of 1.0 x 10-13 mol/L (S/N 3) was reached in the detection of MEL. Moreover, further tests for analyzing MEL structural analogues proved that the constructed ECL sensing platform could be utilized to detect various substances via specific recognitions
Template and target information: melamine, MEL
Author keywords: molecular imprinted polymers, Electrochemiluminescence (ECL), PET-RAFT cross-linking polymerization, Melamine, Ru(bpy)


  Periodic table Coach hat  Science peptide mug  We need to talk about Kelvin shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner