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Reference type: Journal
Authors: Gardouh AR, Barakat BM, Qushawy MKE, El-kazzaz AY, Sami MM, Zaitone SA
Article Title: Antitumor activity of a molecularly imprinted nanopreparation of 5-flurouracil against Ehrlich's carcinoma solid tumors grown in mice: Comparison to free 5-flurouracil.
Publication date: 2018
Journal: Chemico-Biological Interactions
Volume: 295
Page numbers: 52-63.
DOI: 10.1016/j.cbi.2018.04.019
Alternative URL: http://www.sciencedirect.com/science/article/pii/S000927971731356X

Abstract: Recently, nanotechnology has received great attention in war against cancer. The present study investigated the antitumor efficacy of molecularly imprinted nanopreparation of 5-fluorouracil (nano-5-FU) against Ehrlich ascites carcinoma (EAC) solid tumors grown in mice. Tumor cells were transplanted into female albino mice. Mice were allocated into 5 groups; Group 1: control EAC bearing mice. Groups 2&3: EAC-bearing mice treated orally with 5-FU (5 and 10 mg/kg) twice weekly. Groups 4&5: EAC bearing mice treated with nano-5-FU (5 and 10 mg/kg) twice weekly. Treatment with nano-5-FU showed higher antitumor effect compared to free 5-FU as indicated by enhanced apoptosis and reduction in tumor weight. Additionally, lower number of mitotic figures and greater area for necrosis were observed in the tumor specimens alongside with a decline in the number of intratumoral proliferating nuclei in comparison to free 5-FU. Furthermore, the results showed a significant down-regulation in tumoral expression of caspase-3 and vascular endothelial growth factor. Together, these results further support the potential of using nanotechnology to enhance anticancer efficacy of 5-FU
Template and target information: 5-flurouracil, 5-FU
Author keywords: Ehrlich's solid tumor, 5-Flourouracil, Molecularly-imprinted nanopreparation, Mouse, precipitation polymerization


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