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Abstract: Ultrasonic-assisted solid-phase extraction via molecularly imprinted nanoparticles followed by HPLC-UV was used for trace determination of sotalol. Under optimized conditions, linear range, limit of detection, and limit of quantification of the proposed method were found to be 20-2000, 7.8, and 24 ng/mL, respectively. The adsorption capacity of sotalol for molecularly imprinted nanoparticles and non-imprinted nanoparticles was determined from the derived Langmuir isotherm and was found to be 31.55 and 15.22 mg/g, respectively. The proposed method was used for the separation of trace amounts of sotalol in human urine samples with acceptable high recoveries more than 94.40% and the inter-day precision with the coefficient of variation lower than 5%
Template and target information: sotalol
Author keywords: Central composite design, adsorption study, Molecularly imprinted nanoparticles, Sotalol, ultrasonic-assisted solid-phase extraction