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Abstract: In this paper, a straightforward method is presented to detect valproic acid after its microextraction. Molecularly imprinted polymer fiber was used in conjunction with chromatography-flame ionization to achieve this goal. A narrow bore silica capillary was adopted as a mold, via the copolymerization of meth acrylic acid-ethylene glycol dimethacrylate imprinted with VPA, to synthesize the fiber. Extraction temperature, extraction time, salt addition, pH, stirring rate, and desorption temperature - all of which are factors that can influence the extraction process - were measured, and adjusted accordingly. Linearity, precision, and detection limits, as analytical elements, were also evaluated under optimum conditions. Readings showed a linear range of 0.03-100 μg L-1 (r2 = 0.998), and the limit of detection was measured as 0.01 μg L-1. The established method was then applied in selective detection of valproic acid in tablet, syrup and human serum samples successfully
Template and target information: valproic acid, VPA
Author keywords: sample preparation, gas chromatography, Serum sample, Flame ionization detector