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Reference type: Journal
Authors: Zhai JQ, Zhao MH, Cao XJ, Li MY, Zhao MP
Article Title: Metal-Ion-Responsive Bionanocomposite for Selective and Reversible Enzyme Inhibition.
Publication date: 2018
Journal: Journal of the American Chemical Society
Volume: 140
Issue: (49)
Page numbers: 16925-16928.
DOI: 10.1021/jacs.8b10848

Abstract: A bionanocomposite with artificial binding pockets for a DNA repair enzyme has been developed by in situ assembly of an affinity protein with a surrounding contact surface of polydopamine on the surface of silica coated magnetic nanoparticles via molecular imprinting reactions. The obtained nanoparticles exhibited antibody-like binding behavior toward the target enzyme with highly specific and efficient inhibition effect. Moreover, the binding and inhibition could be flexibly tuned by the addition of metal ions such as Mn2+ and Mg2+, which provided a convenient tool to regulate enzyme activity with artificially engineered nanoinhibitors
Template and target information: protein, enzyme

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