MIPs logo MIPdatabase      Special issue call for papers   
Custom Search
Reference type: Journal
Authors: Bangaleh Z, Sadeghi HB, Ebrahimi SA, Najafizadeh P
Article Title: A New Potentiometric Sensor for Determination and Screening Phenylalanine in Blood Serum Based on Molecularly Imprinted Polymer.
Publication date: 2019
Journal: Iranian Journal of Pharmaceutical Research
Volume: 18
Issue: (1)
Page numbers: 61-71.
DOI: 10.22037/ijpr.2019.2340
Alternative URL: http://ijpr.sbmu.ac.ir/article_2340.html

Abstract: Methods routinely utilized for detection of phenylalanine in new-born blood consist of enzymatic assays, lacking sensitivity and HPLC assays which are expensive and time-consuming to conduct. We, here, report for the first time, the construction of a phenylalanine sensitive electrode, on the basis of a selective molecularly imprinted polymer, offering sensitivity, economy and ease of use for the measurement of phenylalanine .The sensor was constructed of a graphite-rod electrode which was coated by MIP embedded polymer base made from polyvinyl chloride and plasticizer mixture, dissolved in THF. At optimized conditions the electrode revealed a Nernstian response 29.73 1.0 mV decade-1 in a concentration range of 1 × 10-8 to 1 × 10-4 M with detection limit of 5 × 10-9 M. The potential response of the electrode was constant in the pH range of 4.0-7.5. The electrode unfolded a response time of ~20 sec. The selectivity coefficient of the sensor towards a number of different amino acids with molecular similarities and some metal ions was evaluated. The sensor was successfully used for determination of phenylalanine in blood serum and the results were in good compatibility with HPLC method
Template and target information: phenylalanine
Author keywords: phenylalanine, potentiometric sensor, Molecular electrochemistry, MIPs

  SMI logo cufflinks  Periodic table Smart hat  Lab Chick script shirt


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner