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Abstract: A magnetic molecularly imprinted polymer (MMIP) for chloramphenicol was prepared using a surface-imprinted and microwave-heating-induced polymerization method. The surfaces of the magnetic particles were first double-bond functionalized with 3-(trimethoxysilyl)propyl methacrylate (γ-MPS), followed by the copolymerization of 4-vinyl pyridine (4-VP) and trimethylolpropane trimethacrylate (TRIM) in the presence of chloramphenicol as a template and 1,1-azobis(cyclohexane-carbonitrile) (ABCN) as an initiator in a mixture of dimethyl sulfoxide and water with microwave heating at 80 ℃ . The magnetic polymer possesses supraparamagnetic properties and was used to concentrate and cleanup chicken feed extract, followed by chromatographic separation using a Lichrospher®100 RP C8 column and detection with two multi-reaction monitoring transitions at m/z 321 → 152 and m/z 321 → 257. The mean recoveries obtained at two spiking levels were in the range of 94.6 - 100% The relative intra- and inter-day standard deviations were in the range of 1.4 - 2.6% and 5.1 - 5.7%, respectively. The detection limit of the method was 0.12 μg kg-1. This confirmatory method was successfully applied to determine chloramphenicol in chicken feed samples
Template and target information: chloramphenicol
Author keywords: Chicken feed, chloramphenicol, Magnetic molecularly imprinted polymers, Microwave heating