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Authors: Sajadi P, Panahi HA, Azarakhshi F
Article Title: Selective extraction and determination of sumatriptan succinate in human urine by synthesized thermosensitive molecularly imprinted poly(3-allyloxy-1, 2-propanediol/N-vinylcaprolactam).
Publication date: 2018
Journal: Separation Science and Technology
Volume: 53
Issue: (18)
Page numbers: 2906-2915.
DOI: 10.1080/01496395.2018.1484768
Abstract: In this research, a drug-imprinted polymer upon polymerization was done with 3-allyloxy-1, 2-propanediol as a functional monomer, N-vinyl caprolactam as a thermosensitive monomer, N, N'-methylenebisacrylamide, as a cross-linker agent, sumatriptan succinate as a template and azobis isobutyronitrile as an initiator. The engineered drug-imprinted polymer was evaluated by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis and scanning electron microscopy. The drug-imprinted polymer sorbent operated selective for sumatriptan succinate. This study examines the determination of sumatriptan succinate in human urine and plasma samples by high-performance liquid chromatography with great results
Template and target information: sumatriptan succinate
Author keywords: Sumatriptan succinate, molecularly imprinted polymer, Solid-phase extraction, Human biological fluids, thermosensitive polymer
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