MIPdatabase
Authors: Tak HY, Yun YH, Lee CM, Yoon SD
Article Title: Sulindac imprinted mungbean starch/PVA biomaterial films as a transdermal drug delivery patch.
Publication date: 2019
Journal: Carbohydrate Polymers
Volume: 208
Page numbers: 261-268.
DOI: 10.1016/j.carbpol.2018.12.076
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0144861718315224
Abstract: In this work, biodegradable biomaterial films for sulindac (SLD) recognition are synthesized from mungbean starch (MBS), PVA, and plasticizers by using UV irradiation process and casting methods. The optimal UV irradiation time for the preparation of SLD imprinted biomaterials films was about 30 min. Mechanical properties, recognition ability, and SLD release property for prepared films were investigated. From the results of recognition ability, we verified that these SLD imprinted biomaterial films have the binding site for SLD. The release properties of SLD was examined with the change of pH and temperature. The results indicate that the SLD release in pH 10.0 was higher than in pH 4.0. SLD release was also evaluated using an artificial skin. Results of the artificial skin test verified that SLD was released constantly for 20 days
Template and target information: sulindac, SLD
Author keywords: Biomaterial films, Sulindac, Physical properties, recognition ability, Drug release property
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