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Reference type: Journal
Authors: Zhang CL, Xiao ZG, Qin TT, Yang ZP
Article Title: Modification of nanocrystalline TiO2 coatings with molecularly imprinted TiO2 for uric acid recognition.
Publication date: 2019
Journal: Journal of Molecular Recognition
Volume: 32
Issue: (6)
Article Number: e2775.
DOI: 10.1002/jmr.2775

Abstract: Combining the surface modification and molecular imprinting technique, a novel piezoelectric sensing platform with excellent molecular recognition capability was established for the detection of uric acid (UA) based on the immobilization of TiO2 nanoparticles onto quartz crystal microbalance (QCM) electrode and modification of molecularly imprinted TiO2 (MIT) layer on TiO2 nanoparticles. The performance of the fabricated biosensor was evaluated, and the results indicated that the biosensor exhibited high sensitivity in UA detection, with a linear range from 0.04 to 45 μM and a limit of detection of 0.01 μM. Moreover, the biosensor presented high selectivity towards UA in comparison with other interferents. The analytical application of the UA biosensor confirmed the feasibility of UA detection in urine sample
Template and target information: uric acid, UA
Author keywords: Highly selective detection, Molecularly imprinted TiO2, Piezoelectric sensing, surface modification, uric acid biosensor

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