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Abstract: New magnetic molecularly imprinted polymers (mag-MIP) were developed for 1-Aminopyrene (1-Ap) detection in human urine samples. 1-Ap is a biomarker for exposure to the 1-Nitropyrenes (as a mutagenic compound) present in the particles emitted from various sources mainly the diesel engines. Fe3O4 (as a magnetic core), TEOS, 1-Ap (as a template), MAA (as a functional monomer), EGDMA (as a cross-linker), and AIBN (as an initiator) were utilized for mag-MIP fabrication in the three-stage processes. Polymer characterization was performed using FTIR, SEM, TEM, and VSM analysis. HPLC-Fl equipment was used for 1-Ap detection. The recoveries and limit of detection were obtained 0.25 μg/ L and 87.2-95.7%, respectively. The results of the nonlinear isotherm and kinetics models had shown maximum adsorption capacity of 51 μg/mg for mag-MIP at relatively short equilibrium time of 30 min for 1-Ap, which was 2.9 times more than magnetic molecularly non-imprinted polymers (mag-NIP). A rapid magnetic separation (13.70 emu/g, 30 s) was observed for mag-MIP applications. Therefore, the present mag-MIP can be successfully used for 1-Ap extraction and detection
Template and target information: 1-aminopyrene, 1-Ap
Author keywords: 1-Aminopyrene, Magnetic molecularly imprinted polymer, human urine, pre-concentration