Reference type: Journal
Authors: Özkan A, Atar N, Yola ML
Article Title: Enhanced surface plasmon resonance (SPR) signals based on immobilization of core-shell nanoparticles incorporated boron nitride nanosheets: Development of molecularly imprinted SPR nanosensor for anticancer drug, etoposide.
Publication date: 2019
Journal: Biosensors and Bioelectronics
Volume: 130
Page numbers: 293-298.
DOI: 10.1016/j.bios.2019.01.053
Alternative URL: https://www.sciencedirect.com/science/article/pii/S095656631930082X

Abstract: An effective SPR nanosensor based on core-shell nanoparticles (Ag@AuNPs) incorporated hexagonal boron nitride (HBN) nanosheets and molecularly imprinted polymer (MIP) was presented for etoposide (ETO) detection. Scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD) method, cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM) methods were utilized for all characterizations of nanomaterials and polymer surfaces. ETO imprinted SPR nanosensor based on Ag@AuNPs-HBN nanocomposite was developed in the presence of poly(2-hydroxyethyl methacrylate-methacryloylamidoglutamic acid) [p(HEMA-MAGA)]. The results of the study have revealed that 0.001-1.00 ng mL-1 (1.70 × 10-12-1.70 × 10-9 M) and 0.00025 ng mL-1 (4.25 × 10-13 M) were found as the linearity range and the detection limit (LOD). Furthermore, the prepared SPR nanosensor was examined in terms of stability, repeatability and selectivity. Finally, the imprinted SPR nanosensor was applied to the urine samples having high recovery
Template and target information: etoposide, ETO
Author keywords: molecular imprinted nanosensor, Etoposide, Core-shell nanoparticles, Hexagonal boron nitride, Urine sample