MIPdatabase
Authors: Pratiwi R, Megantara S, Rahayu D, Pitaloka I, Hasanah AN
Article Title: Comparison of Bulk and Precipitation Polymerization Method of Synthesis Molecular Imprinted Solid Phase Extraction for Atenolol using Methacrylic Acid.
Publication date: 2019
Journal: Journal of Young Pharmacists
Volume: 11
Issue: (1)
Page numbers: 12-16.
DOI: 10.5530/jyp.2019.11.3
Alternative URL: https://www.jyoungpharm.org/article/1306
Abstract: Objective: Atenolol is one of beta-blocker are prohibited as doping based on World Anti-Doping Agency (WADA). The purpose of this study was to the synthesis of molecular imprinted polymer (MIP) for extraction of atenolol from the sample. Method: This research compared the two of the method, bulk and precipitation polymerization. The MIP was successfully prepared from methacrylic acid as a functional monomer, ethyleneglycoldimethacrylate as a crosslinker, benzoyl peroxide as an initiator, butanol as a porogenic solvent with atenolol as a template molecule. Result: The result showed that the bulk polymerization method produces sorbents that have good adsorption capacity and small particle compare to the precipitation polymerization. Both methods were selective for atenolol. Conclusion: Generally, the MIP solid phase extraction is an alternative method for extraction atenolol from the sample.
Template and target information: atenolol
Author keywords: atenolol, molecular imprinted polymer, solid phase extraction
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