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Authors: Gast M, Sobek H, Mizaikoff B
Article Title: Selective virus capture via hexon imprinting.
Publication date: 2019
Journal: Materials Science and Engineering: C
Volume: 99
Page numbers: 1099-1104.
DOI: 10.1016/j.msec.2019.02.037
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0928493118335793
Abstract: An imprinting technique has been developed to generate synthetic polymer beads suitable for selectively binding a supramolecular target. The viral hexon protein, which is the most abundant and accessible surface protein component of the human Adenovirus type 5 (hAdV5) icosahedral capsid, was applied as the template molecule to generate functional polymer beads entailing selectivity for the entire virus. Individual and competitive rebinding studies using two different viruses (i.e. hAdV5 and Minute Virus of Mice - MVM) revealed exquisite selectivity of the imprinted beads for the target hAdV5. Additionally, the morphology of thus imprinted beads was checked via scanning electron microscopy (SEM)
Template and target information: protein, viral hexon protein, virus, human Adenovirus type 5, hAdV5
Author keywords: molecular imprinting, protein imprinting, virus, Hexon protein, Epitope imprinting, Human Adenovirus type 5 (hAdV5), Quantitative polymerase chain reaction (qPCR)
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