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Reference type: Journal
Authors: Fa SX, Zhao Y
Article Title: Synthetic nanoparticles for selective hydrolysis of bacterial autoinducers in quorum sensing.
Publication date: 2019
Journal: Bioorganic & Medicinal Chemistry Letters
Volume: 29
Issue: (8)
Page numbers: 978-981.
DOI: 10.1016/j.bmcl.2019.02.016
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0960894X19300903

Abstract: N-acyl homoserine lactones (AHLs) are signal molecules used by a large number of gram-negative bacteria in quorum sensing and their hydrolysis is known to inhibit biofilm formation. Micellar imprinting of AHL-like templates with catalytic functional monomers yielded water-soluble nanoparticles with AHL-shaped active site and nearby catalytic groups. Either Lewis acidic zinc ions or nucleophilic pyridyl ligands could be introduced through this strategy, yielding artificial enzymes for the hydrolysis of AHLs in a substrate-selective fashion
Template and target information: N-acyl homoserine lactones, AHLs
Author keywords: quorum sensing, autoinducer, molecular imprinting, catalysis, Micelle

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