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Abstract: The molecularly imprinted microspheres,(MIMs) for high performance liquid chromatography were synthesized by aqueous micro-suspension polymerization. The. acidic indometacin, one of. the antidepressants, was used as the template and basic 4- vinylpyridine was used as functional monomer. The influences, of pH of mobile phase on the capacity factor W separation factor(alpha) and selection factor(beta) of indometacin were investigated in detail. All the results showed that the, MIMs exhibited specific recognition and affinity to indometacin only in pH<4.0 eluent; and the specific recognition of MIMs was lost gradually in pH>4.0 eluent. By comparing the retention behavior of indometacin and 4-aminopyridine (4-AP) on the MIMs column, it proved that the recognition of MIMs. to indomeatcin synthesized by 4-vinylpyridine as a cross-linker mainly relied on the ion-pair interaction between the nitrogen atom on the pyridine ring and the carboxyl on the indometacin, and the pi- pi interaction between the pyridine ring and the template molecule. This was just contrary to that MIMs synthesized by methacrylic acid as the cross-linker
Template and target information: indometacin