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Abstract: An electrochemical sensor based on hollow silver nanospheres (hAgNS) and molecularly imprinted polymer (MIP) was developed for drug analysis by using carbamazepine (CBZ) as a model analyte. hAgNS, serving as a support material for MIP immobilization, possesses large accessible surface area with superb electric conductivity, while electrochemically synthesized MIP film warrants improved selectivity for CBZ. Quantification based on the "MIP/gate effect" was performed by employing Fe(CN)6 3-/4- as the probe to indicate the current intensity. The sensor materials were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Under the optimal conditions, a linear relationship of the electrical signal versus the concentration of CBZ was obtained in the range from 8.0 × 10-11 to 6.0 × 10-8 M with a detection limit of 3.2 × 10-11 M (S/N = 3). Moreover, the prepared sensor exhibited specific detection of CBZ over its structural analogues and interferents, and the established electrochemical method was validated using the standard method-high performance liquid chromatography (HPLC). Eventually, rapid and accurate determination of CBZ in rat serum and cell samples was carried out after easy sample pretreatment
Template and target information: carbamazepine, CBZ
Author keywords: Hollow silver nanospheres, molecularly imprinted polymer, electropolymerization, Carbamazepine, Rat serum, Cell samples