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Abstract: During the last decade, templating polymers using molecular imprinting has developed into an efficient strategy for the creation of selective synthetic receptor materials based on cross-linked polymeric networks. However, incubation studies and scavenger applications using conventional molecularly imprinted polymers (MIPs) are rather time consuming, as they require centrifugation and extraction steps. An innovative method circumnavigating this problem is the use of magnetic particles facilitating separations via magnetic field. Nowadays, magnetic materials and especially nanoparticles find widespread applications in analytical chemistry, medicine, and biotechnology. Consequently, combining molecularly imprinting materials with magnetic properties provides a new class of smart synthetic receptors, i.e., magnetic molecularly imprinted polymers (MMIPs). This review gives an overview on these multifunctional materials prepared for biomacromolecules such as enzymes, proteins, DNA and viruses including synthesis, applications and also highlights future trends and perspectives in this emerging research field
Template and target information: review - magnetic core-shell MIPs for biomolecules
Author keywords: magnetic nanoparticles, Magnetic molecularly imprinted polymers, Core-shell molecularly imprinted polymers, surface imprinting, protein imprinting, Biomacromolecules, molecular recognition, separation, Stimuli-responsive polymer